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In 1350, the people of Cambridge are struggling to overcome the effects of the Black Death - and with a high mortality rate among priests and monks, the townsfolk are vulnerable to sinister cults that have sprung up.

At Michaelhouse, Matthew Bartholomew is training new physicians when the body of a friar is found in the massive chest that the University uses to store precious documents. While investigating, Bartholomew stumbles across a derelict church being used as a meeting place for the mysterious sect he believes is at the heart of a web of blackmail and deceit - with intention to overthrow the established religion.