In an alchemical ritual gone wrong, Edward Elric lost his arm and his leg, and his brother Alphonse became nothing but a soul in a suit of armor. Equipped with mechanical "auto-mail" limbs, Edward becomes a state alchemist, seeking the one thing that can restore his brother and himself...the legendary Philosopher's Stone.

The horrors of the Ishbalan campaign occurred years before Ed became a state alchemist, and had serious repercussions, which set the tone for the complicated dealings of present-day state politics. Lieutenant Hawkeye reluctantly tells Ed all the dread details of the role Colonel Mustang and the other state alchemists played in this tragic event.