In an alchemical ritual gone wrong, Edward Elric lost his arm and his leg, and his brother Alphonse became nothing but a soul in a suit of armor. Equipped with mechanical "auto-mail" limbs, Edward becomes a state alchemist, seeking the one thing that can restore his brother and himself...the legendary Philosopher's Stone.

Ed and Al come face to face with the "father" of the homunculi, who just so happens to be a dead ringer for their own father, Van Hohenheim -- a resemblance too uncanny for coincidence. And later, when the allure of immortality proves to be too much for Prince Lin of Xin, he lets Greed take over...literally!